(-)-Indolactam V is a PKC activator (Kis: 3.36 nM, 1.03 μM for η-CRD2, γ-CRD2). (-)-Indolactam V also has the Kds are 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B). It has antitumor activity.
-Indolactam V.gif)
| Pack Size | Availability | Price/USD | Quantity |
|---|---|---|---|
| 1 mg | 6-8 weeks | $ 185 | |
| 2 mg | 6-8 weeks | $ 333 | |
| 4 mg | 6-8 weeks | $ 532 | |
| 10 mg | 6-8 weeks | $ 1099 | |
| 20 mg | 6-8 weeks | $ 1648 |
| Description | (-)-Indolactam V is a PKC activator (Kis: 3.36 nM, 1.03 μM for η-CRD2, γ-CRD2). (-)-Indolactam V also has the Kds are 5.5 nM (η-C1B), 7.7 nM (ε-C1B), 8.3 nM (δ-C1B), 18.9 nM (β-C1A-long), 20.8 nM (α-C1A-long), 137 nM (β-C1B), 138 nM (γ-C1A), 213 nM (γ-C1B). It has antitumor activity. |
| Targets&IC50 | PKCε-C1B:7.7 nM （kd）, PKCθ-C1B:8.7 nM （kd）, PKCη-CRD2:3.36 nM （ki）, PKCη-C1B:5.5 nM （kd）, PKCγ-C1A:138 nM （kd）, PKCβ-C1B:137 nM （kd）, PKCα-C1A-long:20.8 nM （kd）, PKCα-C1B-long:4000 nM （kd）, PKCγ-CRD2:1030 nM （ki）, PKCε-C1A:4110 nM （kd）, PKCδ-C1A:1900 nM （kd）, PKCδ-C1B:8.3 nM （kd）, PKCβ-C1A-long:18.9 nM （kd）, PKCγ-C1B:213 nM （kd）, PKCη-C1A:3770 nM （kd） |
| Synonyms | Indolactam V |
| CAS No. | 90365-57-4 |
| Chemical Formula | C17H23N3O2 |
| Molecular Weight | 301.39 |
| Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
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