Purdue Bioscience - SpeciPure

TP-064 is a potent and selective PRMT4 inhibitor. TP-064 includes inhibition of PRMT4 with IC50 < 10nM for methylation of H3 (1-25) and greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. TP-064 inhibits the methylation of MED12 with IC50 = 43 nM in cell.

Pack Size	Availability	Price/USD
2 mg	In stock	$ 79
4 mg	In stock	$ 150
8 mg	In stock	$ 187
20 mg	In stock	$ 394
40 mg	In stock	$ 618

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Description	TP-064 is a potent and selective PRMT4 inhibitor. TP-064 includes inhibition of PRMT4 with IC50 < 10nM for methylation of H3 (1-25) and greater than 100-fold selectivity over other histone methyltransferases and non-epigenetic targets. TP-064 inhibits the methylation of MED12 with IC50 = 43 nM in cell.
Targets&IC50	MED12:43 nM(IC50), BAF155:340 nM(IC50)
Synonyms	TP 064, TP064
CAS No.	2080306-20-1
Chemical Formula	C28H34N4O2
Molecular Weight	458.606
Solubility	DMSO: 125mg/mL (272.57mM), ultrasonic and warming and heat to 60℃
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

TP-064

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