Purdue Bioscience - SpeciPure

TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).

Pack Size	Availability	Price/USD
1 mg	In stock	$ 219
2 mg	In stock	$ 372
4 mg	In stock	$ 520
10 mg	In stock	$ 1234
20 mg	In stock	$ 1851

Description	TPPB is a kinase C activator of cell-permeable benzolactam-derived protein (Ki: 11.9 nM).
Targets&IC50	PKC:11.9 nM (ki)
In vitro	TPPB inhibits the activation of caspase-3 induced by Aβ25-35. TPPB could increase the phosphorylation of Akt, PKC, MARCKS, and MAPK, which are inhibited by Aβ25-35 treatment. TPPB at a concentration of 1 μM could antagonize Aβ25-35 induced cell damage. By the use of a cell line derived from an Alzheimer’s disease patient, significant enhancement of sAPPα secretion is achieved at 1 μM concentration for TPPB. TPPB has a role against Aβ25-35-induced neurotoxicity in PC12 cells .
In vivo	TPPB is evaluated for the induction of hyperplasia displays a modest response at 300 μg after topical application to the shaved backs of outbred Sencar mice and .
CAS No.	497259-23-1
Chemical Formula	C27H30F3N3O3
Molecular Weight	501.55
Solubility	DMSO: 125 mg/mL (249.23 mM), Need ultrasonic
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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TPPB

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