ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
2 mg | In stock | $ 107 | |
4 mg | In stock | $ 203 | |
8 mg | In stock | $ 289 | |
20 mg | In stock | $ 565 | |
40 mg | In stock | $ 864 |
Description | ZL0580 induces HIV suppression by inhibiting Tat transactivation and transcription elongation as well as by inducing repressive chromatin structure at the HIV promoter. |
In vitro | In PBMCs of viremic HIV-infected individuals,ZL0580 (8 μM, 2 days) induces HIV transcriptional suppression with low toxicity. ZL0580 treatment (10 μM) suppresses both PMA-stimulated and basal HIV transcription. |
CAS No. | 2377151-10-3 |
Chemical Formula | C25H23F3N4O4S |
Molecular Weight | 532.54 |
Solubility | DMSO: 250 mg/mL (469.46 mM), Need ultrasonic |
Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
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