ZINC69391 is a selective inhibitor of Rac1 with antiproliferative and antimetastatic effects. ZINC69391 interferes with the interaction of Rac1 with Dock180, reduces Rac1-GTP levels and induces apoptosis.
| Pack Size | Availability | Price/USD | Quantity |
|---|---|---|---|
| 1 mg | In stock | $ 148 | |
| 2 mg | In stock | $ 251 | |
| 4 mg | In stock | $ 401 | |
| 10 mg | In stock | $ 744 | |
| 20 mg | In stock | $ 1138 |
| Description | ZINC69391 is a selective inhibitor of Rac1 with antiproliferative and antimetastatic effects. ZINC69391 interferes with the interaction of Rac1 with Dock180, reduces Rac1-GTP levels and induces apoptosis. |
| In vitro | In U-87 MG and LN229 cells, ZINC69391 (0-125 μM) reduces cell proliferation of human glioma cells. ZINC69391 (50-100 μM) triggers cell cycle arrest. ZINC69391 inhibits the growth of U937, HL-60, KG1A, and Jurkat cells (IC50s = 41-54 μM). In HL-60, U937, and KG1A cell lines, ZINC69391 (50 μM) triggers an increase in apoptotic cells. In LN229 cells, ZINC69391 (50 and 100 μM) augments the enzymatic activity of caspase 3 and increases the percentage of cells in the sub-G0/G1 phase in a concentration-dependent manner. |
| In vivo | In specific pathogen-free female BALB/c inbred mice (bearing F3II cells), ZINC69391 (25 mg/kg; i.p) impairs metastatic lung colonization and reduces by about 60% the formation of total metastatic lung colonies. |
| Synonyms | ZINC-69391, ZINC 69391 |
| CAS No. | 303094-67-9 |
| Chemical Formula | C14H14F3N5 |
| Molecular Weight | 309.296 |
| Solubility | DMSO: 20 mg/mL (64.66 mM), ultrasonic and warming and heat to 60°C |
| Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
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