Purdue Bioscience - SpeciPure

NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also enhances the apoptotic effect and has anti-cancer activity.

Pack Size	Availability	Price/USD
1 mg	In stock	$ 106
2 mg	In stock	$ 201
4 mg	In stock	$ 270
10 mg	In stock	$ 598
20 mg	In stock	$ 902

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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Description	NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also enhances the apoptotic effect and has anti-cancer activity.
Targets&IC50	Aurora A:67 nM, Aurora B:35 nM, CDK5/p25:15 μM, CDK4/CyclinD:5.5 μM, CDK7/cyclinH:3.9 μM, CDK2/CyclinA:0.41 μM, CDK1/CyclinB:6.6 μM
In vitro	NU6140 enhances catalytic activity of capase-9 and capase-3, causes an increase in the sub-G1 apoptotic cell population. NU6140 is less active on CDK1-cyclin B, CDK4-cyclin D, CDK5-p25 and CDK7-cyclin H (IC50s: 6.6, 5.5, 15 and 3.9 μM, respectively).
CAS No.	444723-13-1
Chemical Formula	C23H30N6O2
Molecular Weight	422.533
Solubility	DMSO: 250 mg/mL (591.69 mM), Need ultrasonic
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

NU6140

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In vivo Formulation Calculator (Clear solution)

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Molarity Calculator allows you to calculate the

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Enter the chemical formula of a compound to calculate its molar mass and elemental composition

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