Purdue Bioscience - SpeciPure

IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 μM).

Pack Size	Availability	Price/USD
1 mg	In stock	$ 107
2 mg	In stock	$ 192
4 mg	In stock	$ 268
10 mg	In stock	$ 578
20 mg	In stock	$ 884

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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Description	IU1-47 is an effective and specific USP14 inhibitor (IC50: 0.6 μM). IU1-47 causes tau elimination in cultured neurons. IU1-47 inhibits IsoT/USP5 (IC50: 20 μM).
Targets&IC50	USP14:0.6 μM, IsoT/USP5:20 μM
In vitro	IU1-47 stimulates tau degradation principally via the ubiquitin-proteasome system. IU1-47 is essentially inactive on free USP14. IU1-47 (25 μM) antagonizes USP14 deubiquitinating activity and stimulates substrate degradation in vitro. IU1-47 (3 μM, 10, and 30 μM; 48 hours) obviously reduces Tau and phosphatase species Ser-202/Thr-205 levels in murine cortical primary neurons.
CAS No.	670270-31-2
Chemical Formula	C19H23ClN2O
Molecular Weight	330.86
Solubility	DMSO: 16.67 mg/mL (50.39 mM), Need ultrasonic
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

IU1-47

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