Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM).
| Pack Size | Availability | Price/USD | Quantity |
|---|---|---|---|
| 1 mg | 6-8 weeks | $ 110 | |
| 2 mg | 6-8 weeks | $ 187 | |
| 4 mg | 6-8 weeks | $ 280 | |
| 10 mg | 6-8 weeks | $ 554 | |
| 20 mg | 6-8 weeks | $ 875 |
| Description | Ilorasertib hydrochloride (ABT-348 hydrochloride) is an ATP-competitive multitargeted kinase inhibitor, which inhibits Aurora C, Aurora B, and Aurora A (IC50s: 1 nM, 7 nM, 120 nM). It also suppresses RET tyrosine kinase, PDGFRβ, and Flt1 (IC50s: 7 nM, 3 nM, and 32 nM). |
| Targets&IC50 | FLT3:1 nM, c-Kit:20 nM, Aurora A:120 nM, PDGFRβ:13 nM, Aurora B (Y156H):12 nM, Aurora B:7 nM, PDGFRα:11 nM, CSF-1R:3 nM, Aurora C:1 nM, VEGFR1:1 nM, VEGFR3:43 nM, VEGFR2:2 nM |
| Synonyms | ABT-348 hydrochloride |
| CAS No. | 1847485-91-9 |
| Chemical Formula | C25H22ClFN6O2S |
| Molecular Weight | 525 |
| Solubility | DMSO: 41.67 mg/mL (79.37 mM), Need ultrasonic |
| Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
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