Purdue Bioscience - SpeciPure

DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.

Pack Size	Availability	Price/USD
5 mg	In stock	$ 120
10 mg	In stock	$ 228
20 mg	In stock	$ 319
50 mg	In stock	$ 558
100 mg	In stock	$ 848

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

IMPORTANT:

Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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Description	DHODH-IN-11 is a leflunomide derivative and weak dihydroorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.03.
Targets&IC50	DHODH:5.03(pKa)
In vitro	A compound structurally related to leflunomide was designed, which contained furan ring (compound 14a). Compound 14a undergoes 4 ring cleavage under physiological pH conditions to obtain the corresponding cyanooxime DHODH-IN-11 (compound 14b). DHODH-IN-14 has been analyzed as a DHODH inhibitor; its inefficiency may be due to the unfavorable stereochemistry of the oxime substructure.
CAS No.	1263303-95-2
Chemical Formula	C15H11N3O2
Molecular Weight	265.272
Solubility	DMSO: 10 mM
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

DHODH-IN-11

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