Purdue Bioscience - SpeciPure

Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.

Pack Size	Availability	Price/USD
1 mg	In stock	$ 83
2 mg	In stock	$ 149
4 mg	In stock	$ 211
10 mg	In stock	$ 397
20 mg	In stock	$ 635

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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Description	Bromosporine is a broad spectrum inhibitor for bromodomains for BRD2/4/9 and CECR2 (IC50: 0.41/0.29/0.122/0.017 μM), respectively.
Targets&IC50	CECR2:0.017 μM, BRD4:0.29 μM, BRD2:0.41 μM, BRD9:0.122 μM
In vitro	Bromosporine (1 μM) accelerates FRAP recovery of BRD4 and CREBBP, while shows no activities against TIF1α, BAZ2A, and SMARCA2 even at 10 μM. Bromosporine (18 μM) has moderate cytotoxicity in HeLa cells.
CAS No.	1619994-69-2
Chemical Formula	C17H20N6O4S
Molecular Weight	404.45
Solubility	DMSO: 51.7 mg/mL
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

Bromosporine

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