Purdue Bioscience - SpeciPure

AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM.

Pack Size	Availability	Price/USD
2 mg	In stock	$ 87
4 mg	In stock	$ 147
8 mg	In stock	$ 231
20 mg	In stock	$ 458
40 mg	In stock	$ 728

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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Description	AI-10-49 is a selective inhibitor of the binding of CBFβ-SMMHC to RUNX1 with IC50 of 260 nM.
Targets&IC50	CBFβ-SMMHC:260 nM
In vitro	AI-10-49 displays specific growth inhibition of inv(16)-positive cell line ME-1. AI-10-49 selectively binds to CBFβ-SMMHC, disrupts its binding to RUNX1, and restores RUNX1 transcriptional activity.
In vivo	In mice transplanted with Cbfb+/MYH11;Nras+/G12D leukemic cells, AI-10-49 (200 mg/kg, i.p.) reduces leukemia expansion.
CAS No.	1256094-72-0
Chemical Formula	C30H22F6N6O5
Molecular Weight	660.533
Solubility	Ethanol: 93 mg/mL (140.8 mM) H2O: <1 mg/mL; DMSO: 93 mg/mL (140.8 mM)
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

AI-10-49

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