Apoptosis

Apoptosis is an autonomous, genetically controlled, orderly death of cells to maintain the stability of the internal environment. Unlike necrosis, apoptosis is not a passive process, but an active one, involving the activation, expression and regulation of a series of genes, and it is not a phenomenon of autologous damage under pathological conditions, but an active death process for better adaptation to the survival environment. Apoptosis is a fundamental biological phenomenon of cells and plays a necessary role in the removal of unwanted or abnormal cells in multicellular organisms. It plays an important role in the evolution of organisms, the stability of the internal environment, and the development of several systems. Apoptosis is not only a specific type of cell death, but also has important biological significance and complex molecular biological mechanisms.

Cat. No.	Product name
BP10990	Z-DEVD-FMK
BP10990	Z-DEVD-FMK is a selective, irreversible Caspase-3 inhibitor, and also exhibits effective inhibition activity on caspase-6, caspase-7, caspase-8, and caspase-10.
BP10846	Zibotentan
BP10846	Zibotentan (ZD4054) is a specific Endothelin (ET)A antagonist with IC50 of 21 nM, exhibiting no activity at ETB. Phase 3.
BP10991	Z-IETD-FMK
BP10991	Z-IETD-FMK is a selective caspase 8 inhibitor, which has cell permeable.
BP10139	Zileuton
BP10139	Zileuton is a synthetic derivative of hydroxyurea with antiasthmatic properties. The leukotriene inhibitor zileuton blocks 5-lipoxygenase, which catalyzes the formation of leukotrienes from arachidonic acid; causes bronchodilation; decreases bronchial mucous secretion and edema; and may prevent or decrease the symptoms of asthma.
BP10636	Zinc Protoporphyrin
BP10636	Zinc Protoporphyrin is an orally active and competitive inhibitor of heme oxygenase-1 (HO-1) and markedly attenuates the protective effects of Phloroglucinol (PG) against H2O2, and has anti-cancer activity.
BP10199	ZINC13466751
BP10199	ZINC13466751 is a potent HIF-1α/von Hippel-Lindau interaction inhibitor(IC50 = 2.0 µM).
BP10774	ZK756326 dihydrochloride
BP10774	ZK756326 dihydrochloride is a agonist of nonpeptide chemokine receptor for the CC chemokine receptor CCR8.
BP10968	ZM 336372
BP10968	ZM 336372 is a potent and selective c-Raf inhibitor.
BP10882	ZM323881 hydrochloride
BP10882	ZZZM 323881 hydrochloride is a potent and selective VEGFR2 inhibitor.
BP10034	ZM39923 hydrochloride
BP10034	ZM 39923 HCl is an JAK1/3 inhibitor with pIC50 of 4.4/7.1, almost no activity to JAK2 and modestly potent to EGFR; also found to be sensitive to transglutaminase.
BP10718	Zoledronic acid monohydrate
BP10718	Zoledronic acid hydrate is a synthetic imidazole bisphosphonate analog with anti-bone-resorption activity.
BP10325	Zoligratinib
BP10325	CH5183284 is a selective and orally available FGFR inhibitor, which is for FGFR1(IC50=9.3 nM), FGFR2(IC50=7.6 nM), FGFR3(IC50=290), and FGFR4(IC50=22 nM), respectively.
BP10692	Zorifertinib
BP10692	AZD3759 is an orally active, effective and central nervous system-penetrant EGFR inhibitor. The IC50 values were 0.2, 0.3 and 0.2 nM for EGFR L858R mutant, TK wild-type, and Exon 19Del enzymes, respectively.
BP10855	Z-VAD(OMe)-FMK
BP10855	Z-VAD(OMe)-FMK is a cell-permeable and irreversible pan-caspase inhibitor. It inhibits cleavage of PARP, preventing apoptosis when used at 10-50 μM.
BP10675	Z-VAD-FMK
BP10675	Z-VAD-FMK (Caspase Inhibitor VI) is an irreversible pan-caspase inhibitor.
BP10992	Z-WEHD-FMK
BP10992	Z-WEHD-FMK is a cell-permeable and irreversible inhibitor of caspase-1/5. It also shows a robust inhibitory effect on cathepsin B activity (IC50: 6 μM).
BP10021	ZZW-115 hydrochloride
BP10021	ZZW-115 hydrochloride inhibits the activity of NUPR1.
BP10109	α-Lipoic Acid
BP10109	Thioctic acid is an octanoic acid bridged with two sulfurs so that it is sometimes also called a pentanoic acid in some naming schemes. It is biosynthesized by cleavage of LINOLEIC ACID and is a coenzyme of oxoglutarate dehydrogenase (KETOGLUTARATE DEHYDROGENASE COMPLEX). It is used in DIETARY SUPPLEMENTS.
BP10589	β-Ionone
BP10589	β-lonone is an end-ring analog of β-carotenoids which widely distributed in fruit and vegetables,with anti-proliferative, anti-metastatic
BP22496	Decitabine
BP22496	Decitabine (NSC 127716) is an orally active deoxycytidine analogue antimetabolite and a DNA methyltransferase inhibitor. Decitabine incorporates into DNA in place of cytosine can covalently trap DNA methyltransferase to DNA causing irreversible inhibition of the enzyme. Decitabine induces cell G2/M arrest and cell apoptosis. Decitabine has potent anticancer activity.