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BP16021
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Etripamil
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Etripamil displays atrioventricular nodal conduction and prolongs atrioventricular nodal refractory periods by inhibiting calcium ion influx through the calcium slow channels in the atrioventricular node cells. Etripamil is an antagonist of short-acting L-type calcium-channel. It has a rapid onset of action designed for intranasal administration. It is also used to treat Paroxysmal Supraventricular Tachycardia.
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BP16022
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Evenamide
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Evenamide is a sodium channel blocker. Which shows efficacy in a broad spectrum of rodent models of psychosis, mania, depression, and aggressiveness.
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BP16023
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Evifacotrep
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Evifacotrep, a short transient receptor potential channel 5 ( TRPC5 ) antagonist (WO2020061162, compound 100), can be used for the research of neurological diseases .
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BP16024
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Fantofarone
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Fantofarone is a highly potent Calcium Channel antagonist.
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BP16025
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Fasoracetam
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Fasoracetam is a modulator of GABA receptor potentially for the treatment of attention deficit hyperactivity disorder.
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BP16026
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Fatostatin hydrobromide
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Fatostatin ia an inhibitor of sterol regulatory element binding protein (SREBP). It impairs the activation of SREBP-1 and SREBP-2.
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BP16027
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FCCP
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FCCP, a potent uncoupler of oxidative phosphorylation in mitochondria, transport protons across cell membranes leading to disrupts ATP synthesis.
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BP16028
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Felbamate
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Felbamate is an Anti-epileptic Agent. The physiologic effect of felbamate is by means of Decreased Central Nervous System Disorganized Electrical Activity.
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BP16029
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FG 7142
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FG 7142 also modulates GABA-induced chloride flux at GABAA receptors expressing the α1 subunit (EC50= 137 nM). FG 7142 can increase tyrosine hydroxylation and cause upregulation of β-adrenoceptors in mouse cerebral cortex. FG 7142, a non-selectively benzodiazepine inverse agonist, has high affinity for the α1 subunit-containing GABAA receptor (Ki=91 nM).
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BP16030
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Fipronil
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Fipronil is a broad-use insecticide that belongs to the phenylpyrazole chemical family. Fipronil is a broad-spectrum insecticide that disrupts the insect central nervous system by blocking GABA-gated chloride channels and glutamate-gated chloride (GluCl) channels, resulting in central nervous system toxicity. This causes hyperexcitation of contaminated insects' nerves and muscles. Specificity of fipronil on insects may come from a better efficacy on GABA receptor, but also because GluCl channels do not exist in mammals.
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BP16031
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Flecainide acetate
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Flecainide (acetate) is a class Ic antiarrhythmic agent used to prevent and treat tachyarrhythmias (abnormal fast rhythms of the heart).
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BP16032
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Flumazenil
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Flumazenil antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous system (CNS), thereby preventing the chloride channel opening events and inhibiting neuronal hyperpolarization. As a result, flumazenil reverses benzodiazepine-induced effects including sedation, psychomotor deficits, amnesia, and hypoventilation in a dose-dependent manner. Flumazenil is an imidazobenzodiazepine derivative, effective in reversing benzodiazepine-induced activities.
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BP16033
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Fluspirilene
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Fluspirilene is a non-competitive L-type calcium channel antagonist (IC50: 0.03 μM). It is a long-acting injectable depot antipsychotic drug used for schizophrenia.
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BP16034
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Fluxametamide
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Fluxametamide is a novel isoxazoline insecticide that acts via distinctive antagonism of insect ligand-gated chloride channels, acts as an antagonist of GABA- and glutamate-gated chloride channels(IC50 of 1.95 nM and 225 nM for M. domestica GABACls and GluCls).
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BP16035
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Fosphenytoin disodium
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Fosphenytoin is a prodrug of phenytoin that is rapidly converted to phenytoin, a voltage-gated sodium channel blocker
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BP16036
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GABAA receptor agent 1
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GABAA receptor agent 1 has strong anticonvulsant activity and is a high affinity ligand of GABAA receptor.
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BP16037
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Gallopamil hydrochloride
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Gallopamil hydrochloride is an antagonist of phenylalkylamine calcium. Gallopamil hydrochloride can be used in antiarrhythmic and vasodilator studies.
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BP16038
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Gefapixant
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Gefapixant is a P2X3 receptor (P2X3R) antagonist with IC50 of ~30 nM at recombinant hP2X3 homotrimers and 100-250 nM at hP2X2/3 heterotrimeric receptors.
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BP16039
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Gidazepam
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Gidazepam is an GABA receptor channels agonist.
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BP16040
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Ginsenoside Rf
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Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.
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