Immunology & Inflammation

Immunology is an act of self-protection of the body against infection and invasion by foreign enemies and the exclusion of foreign molecules, including dead cells of the aging self. The immune response is divided into specific and non-specific, and the general term antigen and antibody responses refer to specific immune responses, which require the participation of B cells and T cells. Other immune cells such as macrophages and NK cells mediate non-specific immune responses and are part of the body's natural defense system. A proper immune response can clear pathogens and is beneficial to the organism. However, an excessive immune response can be harmful to the organism itself. Inflammation is one of the results of a violent immune response.

Cat. No.	Product name
BP14942	(-)-Praeruptorin A
BP14942	(-)-Praeruptorin A has anti-inflammatory, anti-contractile and anti-hyperplasia activities, it exerts distinct relaxant effects on isolated rat aorta rings dependent on endothelium and nitric oxide synthesis;it also can significantly suppress airway inflammation and airway remodeling induced by ovalbumin challenge, and is a potential candidate for the treatment of asthma. (-)-Praeruptorin A resensitizes Pgp-mediated MDR (Pgp-MDR) cancer cells to cancer drugs.
BP14943	1-Hydroxypinoresinol 1-O-glucoside
BP14943	(+)-1-Hydroxypinoresinol 1-O-beta-D-glucoside exhibits peroxynitrite, total ROS and DPPH radical scavenging activities with IC50 values of 3.23 +/- 0.04, 2.26 +/- 0.07 and 32.3 +/- 0.13 microM, respectively.
BP14944	(+)-Catechin Hydrate
BP14944	(+)-Catechin Hydrate is an antioxidant flavonoid of plant origin; a free radical scavenger, preventing free radical-mediated damage in a variety of biological systems.
BP14945	(+)-Usnic acid
BP14945	(+)-Usniacin is a naturally occurring dibenzofuran derivative found in several lichen species.
BP14946	3,9-Dihydroeucomin
BP14946	(+/-)-3,9-Dihydroeucomin has immunomodulatory effects, it shows inhibitory effects on PBMC proliferation activated by PHA with the IC(50) value of 19.4 microM.
BP14947	(±)-Catechin
BP14947	(±)-Catechin hydrate is a natural product,has antioxidant activity and is effective in reducing oxidative stress.
BP14948	N-Benzoyl-(2R,3S)-3-phenylisoserine
BP14948	(2R, 3S)-N-Benzoyl-3-phenylisoserine is an intermediate in the preparation of potent anticancer drug Paclitaxel used to study the location of the binding sites. It shows cytotoxic, antiviral and immunomodulatory activity.
BP14949	Germacrone 4,5-epoxide
BP14949	(4S,5S)-(+)-Germacrone-4,5-epoxide inhibits certain subtypes of cytochrome P450 (CYP).
BP14950	(R)-Reticuline
BP14950	(R)-Reticuline is the biosynthetic precursor of the morphinan alkaloids.
BP14951	(S)-(+)-Ibuprofen D3
BP14951	(S)-(+)-Ibuprofen D3 is a deuterium labeled (S)-(+)-Ibuprofen. (S)-(+)-Ibuprofen is the S(+)-enantiomer of Ibuprofen,it is an inhibitor of COX-1 and COX-2 activity (IC50s of 2.1 μM and 1.6 μM).
BP14952	(Z)-SU4312
BP14952	(Z)-SU4312 is a inhibitor of MAO-B and NOS(IC50 value of 0.2 μM, 19.0μM,respectively).
BP14953	1,3,6-Tri-O-galloyl-beta-D-glucose
BP14953	1,3,6-Tri-O-galloyl-beta-D-glucose is a phenolic compound in Black Walnut Kernels. It shows anti-inflammatory activity.
BP14954	1,5,6-Trihydroxy-3-methoxyxanthone
BP14954	1,5,6-Trihydroxy-3-methoxyxanthone exhibits scavenging activity at 10 uM, it can reduce the viability of HL-60 cells significantly with IC50 values of 28.9 uM.
BP14955	trans-Cinnamaldehyde
BP14955	Cinnamic aldehyde exhibits excellent anti-inflammatory activities and antidepressant-like effects in stressed mid-aged rats as a COX-2 inhibitor. Cinnamic aldehyde induces apoptosis of CML cells in vitro, down-regulation of the expression and function of BCR-ABL may be one of its most important anti-leukemia mechanisms. Cinnamic aldehyde and cinnamic acid are cardioprotective in a rat model of ischemic myocardial injury, the mechanism is related to anti-oxidative and anti-inflammatory properties.
BP14956	Apigenin 7-glucoside
BP14956	Cosmosiin is a anti-HIV agent. Cosmosiin may be beneficial for diabetic complications through their enhanced adiponectin secretion, tyrosine phosphorylation of insulin receptor-β and GLUT4 translocation.
BP14957	Dehydrodiisoeugenol
BP14957	Dehydrodiisoeugenol has anti-inflammatory activity. (1). Dehydrodiisoeugenol inhibited the expression of the COX-2 in RAW264.7 murine macrophages stimulated with LPS. (2). Dehydrodiisoeugenol inhibited LPS-stimulated phosphorylation-dependent proteolysis of inhibitor κB-α and transcriptional activity of NF-κB in the cells.
BP14958	Epigoitrin
BP14958	Epigoitrin has anti-virus activity. Epigoitrin has anti-oxidant activity. 3. Epigoitrin has anti-inflammation activity.
BP14959	(E)-Ethyl p-methoxycinnamate
BP14959	Ethyl 4-methoxycinnamate is an anticarcinogenic agent. Ethyl 4-methoxycinnamate is a glutathion S tranferase inhibitor.
BP14960	Isofraxidin
BP14960	Isofraxidin protects leukemia cells from radiation-induced apoptosis via ROS/mitochondria pathway in a p53-independent manner. Isofraxidin has a protective effect against LPS-induced ALI, and the protective effect of Isofraxidin seems to result from the inhibition of COX-2 protein expression in the lung, which regulates the production of PGE2. Isofraxidin possesses significant analgesic and anti-inflammatory activities that may be mediated through the regulation of pro-inflammatory cytokines, TNF-α and the phosphorylation of p38 and ERK1/2.
BP14961	L-Arginine
BP14961	L-Arginine exhibits anti-atherosclerotic effect. L-Arginine and soy enriched diet are effective in prevention of osteoporosis associated with diabetes mellitus. Exogenous L-Arginine could enhance neonate lymphocyte proliferation through an interleukin-2-independent pathway. A combination of oral L-citrulline and L-Arginine effectively and rapidly augments NO-dependent responses at the acute stage.