Purdue Bioscience - SpeciPure

Pack Size	Availability	Price/USD
5 mg	8-10 weeks	$ 1023
10 mg	8-10 weeks	$ 1943
20 mg	8-10 weeks	$ 2761
50 mg	8-10 weeks	$ 6091
100 mg	8-10 weeks	$ 9623

Description	YM-46303 is an antagonist of mAChR
In vivo	Compared with oxybutynin, YM-46303 showed about 10 times higher inhibitory activity on bladder pressure during reflex rhythmic contractions, and increased selectivity of bladder contraction about saliva secretion in rats by about 5 times. Further evaluation of antimuscarinic effects on bradycardia and pressor in pithed rats, and on tremor in mice, show that YM-46303 can be useful for the treatment of urinary urge incontinence as a bladder-selective M3 antagonist with potent activities and fewer side effects. YM-46303 shows in vivo selective inhibitory activities on bladder pressure in reflexly-evoked rhythmic contraction against oxotremorine-induced salivary secretion. In addition, YM-46303 has potent activity in a guinea pig model of methacholine-induced bronchospasm on intravenous administration.
CAS No.	171722-81-9
Chemical Formula	C20H23ClN2O2
Molecular Weight	358.87
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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YM-46303

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