Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug.
| Pack Size | Availability | Price/USD | Quantity |
|---|---|---|---|
| 5 mg | 2-3 weeks | $ 70 | |
| 10 mg | 2-3 weeks | $ 133 | |
| 20 mg | 2-3 weeks | $ 178 | |
| 50 mg | 2-3 weeks | $ 421 | |
| 100 mg | 2-3 weeks | $ 648 |
| Description | Latrepirdine is an orally active, and neuroactive antagonist of multiple drug targets, including histamine receptors, GluR, and 5-HT receptors, used as an antihistamine drug. |
| In vitro | Latrepirdine increases succinate dehydrogenase activity (MTT-assay), mitochondrial membrane potential (DeltaPsim), and cellular ATP levels in primary mouse cortical neurons and human neuroblastoma cells (SH-SY5Y). Latrepirdine enhances mitochondrial function both in the absence and presence of stress and Dimebon-treated cells are partially protected to maintain cell viability. Latrepirdine leads to enhanced mTOR- and Atg5-dependent autophagy in cultured mammalian cells. latrepirdine stimulates MTOR- and ATG5-dependent autophagy, leading to the reduction of intracellular levels of APP metabolites, including Aβ in cultured cells. Latrepirdine stimulates the degradation of α-syn in differentiated SH-SY5Y neurons, and in mouse brain following chronic administration, in parallel with elevation of the levels of markers of autophagic activity. Latrepirdine increases intracellular ATP levels and glucose transporter 3 translocation to the plasma membrane in primary neuron. |
| In vivo | Latrepirdine treatment of TgCRND8 transgenic mice is associated with improved learning behavior and with a reduction in accumulation of Aβ42 and α-synuclein. Latrepirdine administration results in increased levels of the biomarkers thought to correlate with autophagy activation in the brains of TgCRND8 (APP K670M, N671L, V717F) or wild-type mice, and that treatment is associated with abrogation of behavioral deficit, reduction in Aβ neuropathology, and prevention of autophagic failure among TgCRND8 mice. |
| Synonyms | Dimebolin, Latrepirdine 2HCl, Dimebolin dihydrochloride, Latrepirdine |
| CAS No. | 97657-92-6 |
| Chemical Formula | C21H27Cl2N3 |
| Molecular Weight | 392.37 |
| Solubility | DMSO: 39.2 mg/mL (100 mM) |
| Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
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