Purdue Bioscience - SpeciPure

Ridaforolimus is a small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamycin (mTOR), which may result in cell cycle arrest and, consequently, the inhibition of tumor cell growth and proliferation. Upregulated in some tumors, mTOR is a serine/threonine kinase involved in regulating cellular proliferation, motility, and survival that is located downstream of the PI3K/Akt signaling pathway.

Pack Size	Availability	Price/USD
5 mg	In stock	$ 90
10 mg	In stock	$ 162
20 mg	In stock	$ 229
50 mg	In stock	$ 494
100 mg	In stock	$ 790

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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Description	Ridaforolimus is a small molecule and non-prodrug analogue of the lipophilic macrolide antibiotic rapamycin with potential antitumor activity. Ridaforolimus binds to and inhibits the mammalian target of rapamycin (mTOR), which may result in cell cycle arrest and, consequently, the inhibition of tumor cell growth and proliferation. Upregulated in some tumors, mTOR is a serine/threonine kinase involved in regulating cellular proliferation, motility, and survival that is located downstream of the PI3K/Akt signaling pathway.
Targets&IC50	mTOR (HT-1080 cells):0.2 nM
Synonyms	MK-8669, Deforolimus, AP23573
CAS No.	572924-54-0
Chemical Formula	C53H84NO14P
Molecular Weight	990.222
Solubility	DMSO: 182 mg/mL (183.8 mM) H2O: <1 mg/mL; Ethanol: <1 mg/mL
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

Ridaforolimus

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