Emetine extracted from the roots of the roots is an effective antiprotozoal and emetic agent, and effectively inhibits autophagy, anti-malarial, anti-bacterial and anti-ameba effects.
| Pack Size | Availability | Price/USD | Quantity |
|---|---|---|---|
| 1 mg | In stock | $ 236 | |
| 2 mg | In stock | $ 401 | |
| 4 mg | In stock | $ 561 | |
| 10 mg | In stock | $ 1389 | |
| 20 mg | In stock | $ 2194 |
| Description | Emetine extracted from the roots of the roots is an effective antiprotozoal and emetic agent, and effectively inhibits autophagy, anti-malarial, anti-bacterial and anti-ameba effects. |
| In vitro | Emetine accumulates SQSTM1 and MAP1LC3B in SNB-19 cells, indicating autophagy is blocked.Emetine dose-dependently decreases NS1 protein level in HEK293 cells infected with the African prototype, ZIKV MR766 (IC50=52.9?nM). Emetine directly inhibits ZIKV NS5 RNA polymerase activity with an IC50 of 121?nM. |
| In vivo | Emetine (1?mg/kg/day; retro-orbital injection; for six days) reduces the levels of circulating ZIKV approximately 10-fold in three-month-old female SJL mice with ZIKVBR.Emetine (0.002, 0.02, 0.2, 2 mg/kg/day; i.p.) not only attenuates blood glucose levels in dose-dependent way but also induces a persistent attenuation of blood glucose levels in C57Bl/6 male mice (20-25 g) . |
| Synonyms | Emetin, Cephaeline methyl ether |
| CAS No. | 483-18-1 |
| Chemical Formula | C29H40N2O4 |
| Molecular Weight | 480.649 |
| Solubility | DMSO: 10 mM |
| Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
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