Purdue Bioscience - SpeciPure

Pack Size	Availability	Price/USD
1 mg	In stock	$ 133
2 mg	In stock	$ 239
4 mg	In stock	$ 378
10 mg	In stock	$ 644
20 mg	In stock	$ 966

Description	Lucanthone is an endonuclease inhibitor of Apurinic endonuclease-1 (APE-1).
In vitro	Lucanthone is a novel inhibitor of autophagy that induces cathepsin D-mediated apoptosis. To investigate the anticancer activity of Lucanthone, cell viability is measured by MTT assay. Lucanthone reduces cell viability to a similar extent in a panel of seven breast cancer cell lines. In addition, a direct comparison reveals that Lucanthone is significantly more potent than Chloroquine (CQ) at reducing breast cancer cell viability with a mean IC50?of 7.2 μM versus 66 μM for CQ. Measurement of cell viability in two representative cell lines (MDA-MB-231 and BT-20) by ATPlite assay and trypan blue exclusion reveals comparable results.
Synonyms	Lucantona, Lucanthonum
CAS No.	479-50-5
Chemical Formula	C20H24N2OS
Molecular Weight	340.49
Solubility	DMSO: 25 mg/mL), Need ultrasonic
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Lucanthone

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