Nicotinamide N-oxide is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyzes the reduction of nicotinamide N-oxide to nicotinamide in the liver is xanthine oxidase.
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|---|---|---|---|
| 100 mg | In stock | $ 93 | |
| 200 mg | In stock | $ 176 | |
| 400 mg | In stock | $ 246 | |
| 1 g | In stock | $ 559 | |
| 2 g | In stock | $ 860 |
| Description | Nicotinamide N-oxide is recognized as an in vivo metabolite of nicotinamide which is a precurser of nicotinamide-adenine dinucleotide (NAD+) in animals. The enzyme that catalyzes the reduction of nicotinamide N-oxide to nicotinamide in the liver is xanthine oxidase. |
| In vitro | Nicotinamide is one of the forms of vitamin B3. It is a precursor for nicotinamide adenine dinucleotide, which is best known as an electron carrier in oxidative phosphorylation and as a cofactor for many dehydrogenases. It is metabolized through two enzymatic systems. The first system starts with the methylation of nicotinamide by nicotinamide N-methyltransferase, which can subsequently be oxidized by aldehyde oxidase. The second enzymatic system oxidizes nicotinamide to nicotinamide N-oxide. A series of nicotinamide N-oxides is synthesized and shown to be novel, potent, and selective antagonists of the CXCR2 receptor. Compound 1 has demonstrated potent inhibition of neutrophil chemotaxis (IC50=10 nM). Compound 2 is a selective antagonist of IL-8 binding (IC50=110 nM) and potent inhibitor of neutrophil chemotaxis (IC50=170 nM). |
| Synonyms | Nicotinamide-N-oxide, 1-oxynicotinamide, Nicotinamide 1-oxide |
| CAS No. | 1986-81-8 |
| Chemical Formula | C6H6N2O2 |
| Molecular Weight | 138.126 |
| Solubility | H2O: Limited solubility DMSO: 8 mg/mL(57.9 mM) |
| Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
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