Purdue Bioscience - SpeciPure

Camptothecin (NSC-100880, CPT, Campathecin, (S)-(+)-Camptothecin) is a specific inhibitor of DNA topoisomerase I (Topo I) with an IC50 of 0.68 μM. Camptothecin induces apoptosis in cancer cells through the microRNA- 125b-mediated mitochondrial signaling pathway to induce apoptosis.

Pack Size	Availability	Price/USD
100 mg	In stock	$ 55
500 mg	In stock	$ 169
1 g	In stock	$ 250
5 g	In stock	$ 800

Description	Camptothecin (NSC-100880, CPT, Campathecin, (S)-(+)-Camptothecin) is a specific inhibitor of DNA topoisomerase I (Topo I) with an IC50 of 0.68 μM. Camptothecin induces apoptosis in cancer cells through the microRNA- 125b-mediated mitochondrial signaling pathway to induce apoptosis.
Targets&IC50	Topoisomerase I:679 nM (IC50): Camptothecins::
In vitro	High TOP1 enzymatic activity MCF7 (Luminal subtype) and HCC1419 (HER2 subtype) show high sensitivity toward Camptothecin (0.1 μM to 5 μM; 72 hours) treatment, exhibiting the IC50 values of 0.089 μM and 0.067 μM, respectively.Camptothecin (0.5 μM; 6 and 24 hours) reduces desferrioxamine-activated VEGF expression.Camptothecin (0.5 μM; 8 to 24 hours) strongly prevents the desferrioxamine-dependent HIF-1a accumulation.
In vivo	Camptothecin (2 mg/kg every other day) treats mice, has developed numerous pulmonary metastases.Treatment with both kinase inhibitor of nuclear factor-kappaB-1 (KINK-1) and Camptothecin led to a statistically significant reduction in the number of pulmonary metastases.
CAS No.	7689-03-4
Chemical Formula	C20H16N2O4
Molecular Weight	348.35
Solubility	DMSO: 6.25 mg/mL (17.94 mM, Need ultrasonic)
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Camptothecin

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