α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes.
| Pack Size | Availability | Price/USD | Quantity |
|---|---|---|---|
| 5 mg | In stock | $ 107 | |
| 10 mg | In stock | $ 181 | |
| 20 mg | In stock | $ 307 | |
| 50 mg | In stock | $ 578 | |
| 100 mg | In stock | $ 924 |
| Description | α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells.α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. |
| In vitro | α-Lipoic Acid (Alpha-Lipoic acid, ALA) is a naturally occurring dithiol compound, plays an essential role in mitochondrial bioenergetics.?It reduces lipid accumulation in the liver by regulating the transcriptional factors SREBP-1, FoxO1, and Nrf2, and their downstream lipogenic targets via the activation of the SIRT1/LKB1/AMPK pathway.?Treatment of cells with α-Lipoic Acid (250, 500 and 1000 μM) significantly increases the NAD+/NADH ratio in HepG2 cells (P<0.05 or P<0.01).?Treatment with α-Lipoic Acid (50, 125, 250 and 500 μM) increases SIRT1 activity in HepG2 cells.?α-Lipoic Acid (50, 125, 250, 500 and 1000 μM) increases phosphorylation of AMPK and acetyl-CoA carboxylase (ACC) in HepG2 cells in a dose-dependent fashion |
| In vivo | Administration of α-Lipoic Acid (100 mg/kg or 200 mg/kg) markedly reduces visceral fat mass in mice.?In addition, α-Lipoic Acid (100 mg/kg or 200 mg/kg) treatment inhibits the appetite and causes a dramatic weight loss (all P<0.05) |
| Synonyms | Lipoic acid, Alphalipoic acid |
| CAS No. | 62-46-4 |
| Chemical Formula | C8H14O2S2 |
| Molecular Weight | 206.32 |
| Solubility | DMSO: 10 mM |
| Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
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