Purdue Bioscience - SpeciPure

AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.

Pack Size	Availability	Price/USD
2 mg	In stock	$ 77
4 mg	In stock	$ 138
8 mg	In stock	$ 204
20 mg	In stock	$ 347
40 mg	In stock	$ 551

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

IMPORTANT:

Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

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Description	AMG319 is a potent and selective PI3Kδ inhibitor with IC50 of 18 nM, >47-fold selectivity over other PI3Ks. Phase 2.
Targets&IC50	PI3Kδ:18 nM
In vitro	AMG319 inhibits anti-IgM/CD40L-induced B cell proliferation with IC50 of 8.6 nM and reduces pAkt level with IC50 of 1.5 nM. AMG319 also inhibits anti-IgD-induce CD-69 expression in HWB.
In vivo	In female Lewis rats, AMG319 (3 mg/kg, p.o.) inhibits the KLH-induced inflammatory response by 88%. In the transgenic (IgMm) mice, AMG319 (, p.o.) inhibits in vivo pAKT with IC50 of 1.9 nM.
CAS No.	1608125-21-8
Chemical Formula	C21H16FN7
Molecular Weight	385.406
Solubility	H2O: <1 mg/mL DMSO: 71 mg/mL (184.2 mM); Ethanol: 71 mg/mL (184.2 mM)
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

AMG319

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In vivo Formulation Calculator (Clear solution)

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Molarity Calculator allows you to calculate the

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