JAK/STAT Pathway

JAK-STAT signaling pathway mediates cell-to-cell signaling and is essential for development, cell differentiation and homeostasis in vivo. The JAK-STAT signaling pathway has many evolutionarily conserved functions, including cell proliferation and hematopoiesis.JAK belongs to a family of non-receptor protein tyrosine kinases, approximately 130 kDa, consisting of JAK1, JAK2, JAK3. STATs are potential cytoplasmic transcription factors that are activated upon recruitment to activated receptor complexes. Seven STAT proteins, STAT1-6, have been identified, including STAT5a and STAT5b (encoded by different genes). Mechanistically, the JAK/STAT signaling pathway is relatively simple, with only a few major component members. Various ligands, including cytokines, hormones and growth factors, and their receptors can activate the JAK/STAT pathway. However, the biological consequences of the activation of this pathway are complicated by its interaction with other signaling pathways.

Cat. No.	Product name
BP15243	APTSTAT3-9R acetate
BP15243	APTSTAT3-9R acetate is a selective peptide binding STAT3 with antiproliferative and antitumor activity. APTSTAT3-9R acetate and inhibits STAT3 activation and downstream signaling by specifically blocking STAT3 phosphorylation.
BP15244	AS1517499
BP15244	AS1517499 is a potent STAT6 inhibitor with IC50 of 21 nM
BP15245	CMD178 TFA
BP15245	CMD178 (TFA) is a lead peptide that consistently reduces the expression of Foxp3 and STAT5 induced by IL-2/s IL-2Rα signaling.
BP15246	Colivelin
BP15246	Colivelin is a neuroprotective peptide and activator of STAT3. Colivelin is a hybrid peptide synthesized to enhance the neuroprotective effects of humanin (HN).
BP15247	Corylin
BP15247	Corylin is a major bioactive compound isolated from Psoralea corylifolia L; it has the activity of antibiotic or anticancer.
BP15248	Eupalinolide I
BP15248	Eupalinolide I is a natural product from Eupatorium lindleyanum.
BP15249	Golotimod (TFA) (229305-39-9 free base)
BP15249	Golotimod (TFA), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function.
BP15250	Golotimod hydrochloride (229305-39-9 free base)
BP15250	Golotimod hydrochloride (SCV 07 hydrochloride), an immunomodulating peptide with antimicrobial activity, significantly increases the efficacy of antituberculosis therapy, stimulates thymic and splenic cell proliferation, and improves macrophage function.
BP15251	Isocryptotanshinone
BP15251	Isocryptotanshinone inhibits protein tyrosine phosphatase 1B (PTP1B) activity with 50% inhibitory concentration values of 56.1±6.3 μM, PTP1B acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes.
BP15252	Kurarinol
BP15252	Kurarinol is a potent inhibitor of sortase A, with an IC50 value of 107.7 ± 6.6 μM. Kurarinol has extremely strong tyrosinase inhibitory activity, exerts varying degrees of inhibition on tyrosinase-dependent melanin biosynthesis, is a candidate as skin-whitening agents.
BP15253	ML115
BP15253	ML115 is a potent and selective activator of transcription 3 (STAT3), with abn EC50 of 2.0 nM, and is inactive against the related STAT1 and NFκB anti-targets.
BP15254	Mogrol
BP15254	Mogrol is a biometabolite of mogrosides. Mogrol acts via inhibition of the ERK1/2 and STAT3 pathways, or reducing CREB activation and activating AMPK signaling.
BP15255	NSC 370284
BP15255	NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo.
BP15256	SH5-07
BP15256	SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 μM).
BP15257	SI-109
BP15257	SI-109 is a potent inhibitor of STAT3 SH2 domain (Ki=9 nM),and with antitumor activity.
BP15258	Stafia-1
BP15258	Stafia-1 is a potent STAT5a inhibitor (IC50=22.2 μM). Stafia-1 displays high selectivity over STAT5b and other STAT family members.
BP15259	STAT3-IN-3
BP15259	STAT3-IN-3 is a potent and selective signal transducer inhibitor and transcription 3 (STAT3) activator.
BP15260	STAT3-IN-B9
BP15260	STAT3-IN-B9 is an inhibitor of abnormal STAT3 activation and inhibits the proliferation of tumor cells including MDA-MB-468, MDA-MB-231, and DU145.
BP15261	STAT5-IN-1
BP15261	STAT5 Inhibitor is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.
BP22553	NSC 74859
BP22553	NSC 74859 (S3I-201) is a selective Stat3 inhibitor with an IC50 of 86 μM.