STAT5 Inhibitor is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain.
| Pack Size | Availability | Price/USD | Quantity |
|---|---|---|---|
| 5 mg | In stock | $ 93 | |
| 10 mg | In stock | $ 158 | |
| 20 mg | In stock | $ 281 | |
| 50 mg | In stock | $ 496 | |
| 100 mg | In stock | $ 793 |
| Description | STAT5 Inhibitor is a cell-permeable inhibitor which suppresses Stat5 via binding to the SH2 domain. |
| Targets&IC50 | STAT5:47 μM |
| In vitro | The signal transducer and activator of transcription 5 (STAT5) is a member of the STAT family of proteins, implicated in cell growth and differentiation. STAT5-IN-1 inhibits STAT5 by binding to the SH2 domain. The functions of the SH2 domains of STAT3, STAT1, and of the tyrosine kinase Lck are inhibited to a lesser extent (IC50>500 μM). STAT5-IN-1 block STAT5/STAT5 DNA binding in K562 nuclear extracts. Substitution of the hydrogen at C6 of the chromone ring by an ethyl group does not affect activity of STAT5-IN-1 against STAT5β, but leads to complete loss of selectivity against other STAT family members |
| Synonyms | STAT5 Inhibitor |
| CAS No. | 285986-31-4 |
| Chemical Formula | C16H11N3O3 |
| Molecular Weight | 293.282 |
| Solubility | DMSO: 23.0 mg/mL |
| Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
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