Purdue Bioscience - SpeciPure

Pack Size	Availability	Price/USD
2 mg	In stock	$ 119
4 mg	In stock	$ 202
8 mg	In stock	$ 299
20 mg	In stock	$ 592
40 mg	In stock	$ 941

Description	SH5-07 is a hydroxamic acid-based Stat3 inhibitor (IC50: 3.9 μM).
Targets&IC50	STAT3:3.9 μM (cell free)
In vitro	SH5-07 is a hydroxamic acid analog of BP-1-102. SH5-07 dose-dependently inhibits Stat3 activity (IC50: 3.9±0.6 μM in in vitro assay). It preferentially inhibits Stat3:Stat3 DNA-binding activity, ahead of inhibiting Stat1:Stat3 activity, with minimal effects on Stat1:Stat1 activity. SH5-07 binds Stat3, disrupts Stat3 association with growth factor receptor, and thereby inhibits Stat3 phosphorylation. It induces antitumor cell effects against malignant cells harboring constitutively-active Stat3. SH5-07 inhibits the expression of known Stat3-regulated genes. Bcl-xL, Bcl-2, c-Myc, Survivin, Cyclin D1, and Mcl-1 expression is reduced in response to 24 h, 5 μM SH5-07 treatment.
In vivo	Tail vein injection or oral gavage delivery of SH5-07 inhibits the growth of 90-150 mm^3 established subcutaneous mouse xenografts of human glioma (U251MG) and breast (MDA-MB-231) tumors that harbor aberrantly-active Stat3, associated with decreased Mcl-1, c-Myc, and Cyclin D1 expression. No significant changes in body weights, blood cell counts, or the gross anatomy of organs, or obvious signs of toxicity are observed.
CAS No.	1456632-41-9
Chemical Formula	C29H28F5N3O5S
Molecular Weight	625.61
Solubility	H2O: Insoluble DMSO: 50 mg/mL (79.92 mM), Need ultrasonic
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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SH5-07

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