Purdue Bioscience - SpeciPure

Eleclazine hydrochloride is a novel inhibitor of late Na+ current (IC50: 0.7 uM).

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20 mg	In stock	$ 1321

Description	Eleclazine hydrochloride is a novel inhibitor of late Na+ current (IC50: 0.7 uM).
Targets&IC50	Na+ current:0.7 uM
In vitro	Inhibition by GS-6615 of ATX-II enhanced late INa is potently correlated with shortening of myocyte APD and isolated heart MAPD. Eleclazine hydrochloride inhibits ATX-II enhanced late INa in ventricular myocytes, shorten the ATX-II induced prolongation of APD, MAPD, QT interval. It also decreased spatiotemporal dispersion of repolarization and ventricular arrhythmias. Selective inhibition of cardiac late INa with eleclazine hydrochloride confers dual protection against vulnerability to ischemia-induced AF. That decreases atrial and ventricular repolarization abnormalities before and during adrenergic stimulation without negative inotropic effects.
Synonyms	GS 6615 hydrochloride
CAS No.	1448754-43-5
Chemical Formula	C21H17ClF3N3O3
Molecular Weight	451.83
Solubility	DMSO: 100 mg/mL (221.32 mM)
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

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Eleclazine hydrochloride

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