Purdue Bioscience - SpeciPure

Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception and thermal hypersensitivity.

Pack Size	Availability	Price/USD
2 mg	In stock	$ 104
4 mg	In stock	$ 176
8 mg	In stock	$ 315
20 mg	In stock	$ 575
40 mg	In stock	$ 879

In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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Description	Eact is a selective and potent TMEM16A activator. It directly activates the TRPV1 channels in sensory nociceptors. Which also produces itch, acute nociception and thermal hypersensitivity.
In vitro	Eact activates membrane currents in mTRPV1-expressing HEK293T cells in a concentration-dependent manner (EC50: 11.6 ± 2.5 μM). Eact induces both itch-and pain- related behaviours in a TRPV1-dependent manner. TMEM16A activator Eact activates both native and recombinant TRPV1 channels.
CAS No.	461000-66-8
Chemical Formula	C22H24N2O5S
Molecular Weight	428.5
Solubility	DMSO: 50 mg/mL (116.69 mM), Need ultrasonic
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

Eact

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In vivo Formulation Calculator (Clear solution)

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