Purdue Bioscience - SpeciPure

AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.

Pack Size	Availability	Price/USD
5 mg	In stock	$ 111
10 mg	In stock	$ 199
20 mg	In stock	$ 300
50 mg	In stock	$ 544
100 mg	In stock	$ 854

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)， Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation ：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

IMPORTANT:

Please refer to the datasheet of our products for more information about solubility. Some auxiliary solubilization methods such as sonication, heating, and vortex shaking may be able to assist in the dissolution of the product.

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Description	AC1903 is a specific inhibitor of TRPC5 channel, and has been shown to suppress severe proteinuria and prevent podocyte loss.
Targets&IC50	TRPC5 current IN HEK-293 cells:14.7 μM (IC50)
In vivo	AC1903, that specifically blocks TRPC5 channel activity in glomeruli of proteinuric rats.?Chronic administration of AC1903 suppressed severe proteinuria and prevented podocyte loss in a transgenic rat model of FSGS.AC1903 also provided therapeutic benefit in a rat model of hypertensive proteinuric kidney disease.?TRPC5 activity drives disease and that TRPC5 inhibitors may be valuable for the treatment of progressive kidney diseases.
CAS No.	831234-13-0
Chemical Formula	C19H17N3O
Molecular Weight	303.365
Solubility	DMSO: 10 mM
Storage	Powder: -20°C for 2 years In solvent: -80°C for 1 year

AC1903

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