Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp.
| Pack Size | Availability | Price/USD | Quantity |
|---|---|---|---|
| 1 mg | In stock | $ 143 | |
| 2 mg | In stock | $ 243 | |
| 4 mg | In stock | $ 340 | |
| 10 mg | In stock | $ 656 | |
| 20 mg | In stock | $ 1049 |
| Description | Phyllanthin is widely used as hepatoprotective and antigenotoxic and inhibit function of P-gp. |
| In vitro | The activity of P-gp and MRP2 was determined in the uptake assays by monitoring the intracellular accumulation of their specific substrates (calcein acetoxymethyl ester and 5(6)-carboxy-2',7'-dichlorofluorescein diacetate, respectively) with fluorescence spectroscopy. HypoPhyllanthin and Phyllanthin inhibited P-gp function with comparable potencies, but neither compound affected MRP2 activity. When the lignans were washed out before addition of substrate, the inhibitory action of both compounds against P-gp function was lost. These results suggested the reversibility of the inhibition. Moreover, prolonged exposure of the Caco-2 cells to both lignans (up to 7 days) had no effect on P-gp function |
| CAS No. | 10351-88-9 |
| Chemical Formula | C24H34O6 |
| Molecular Weight | 418.53 |
| Solubility | DMSO: 55 mg/ml (131.42 mM) |
| Storage | Powder: -20°C for 2 years In solvent: -80°C for 1 year |
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