Immunology & Inflammation

Immunology is an act of self-protection of the body against infection and invasion by foreign enemies and the exclusion of foreign molecules, including dead cells of the aging self. The immune response is divided into specific and non-specific, and the general term antigen and antibody responses refer to specific immune responses, which require the participation of B cells and T cells. Other immune cells such as macrophages and NK cells mediate non-specific immune responses and are part of the body's natural defense system. A proper immune response can clear pathogens and is beneficial to the organism. However, an excessive immune response can be harmful to the organism itself. Inflammation is one of the results of a violent immune response.

Cat. No.	Product name
BP15242	Carrageenan
BP15242
BP22477	MCC950
BP22477	MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 with IC50 values of 7.5 and 8.1 nM in BMDMs and HMDMs, respectively. nM and 8.1 nM in BMDMs and HMDMs, respectively.
BP22567	Concanamycin A
BP22567	Concanamycin A (Folimycin; Antibiotic X 4357B) is a macrolide antibiotic, a vacuolar type H+-ATPase (V-ATPase) inhibitor. Concanamycin A is also an inhibitor of lysosomal acidification, can be used to T cell-mediated inflammation research-.
BP22568	Fidaxomicin
BP22568	Fidaxomicin (OPT-80), a macrocyclic antibiotic, is an orally active and potent RNA polymerase inhibitor. Fidaxomicin has a narrow spectrum of antibacterial activity and a good anti-Clostridium difficile activity (MIC90=0.12 μg/mL). Fidaxomicin can be used for Clostridium difficile infection (CDI) research.
BP22482	TLR4-IN-C34
BP22482	TLR4-IN-C34 (TLR4-C34, C34, TLR4-C34-IN) is a potent and selective antagonist of Toll-like receptor 4 (TLR4).TLR4-IN-C34 reduces endotoxemia and systemic inflammation in a mouse model of necrotizing small intestinal colitis.
BP22495	Cyclosporin A
BP22495	Cyclosporin A (Cyclosporine A) is an immunosuppressant which binds to the cyclophilin and inhibits phosphatase activity of calcineurin with an IC50 of 5 nM. Cyclosporin A also inhibits CD11a/CD18 adhesion[8].
	Calcipotriol
	Calcipotriene (Calcipotriol, MC903) is a synthetic derivative of calcitriol that induces differentiation of keratinocytes, inhibits their proliferation, reverses abnormal changes of keratinocytes in psoriasis, and promotes normal epidermal growth.
BP22566	Staurosporine
BP22566	Staurosporine is a potent, ATP-competitive and non-selective inhibitor of protein kinases with IC50s of 6 nM, 15 nM, 2 nM, and 3 nM for PKC, PKA, c-Fgr, and Phosphorylase kinase respectively. Staurosporine also inhibits TAOK2 with an IC50 of 3 μM. Staurosporine is an apoptosis inducer.
BP22573	Chlorobutanol
BP22573	Chlorobutanol is a pharmaceutical preservative. Chlorobutanol is active against a wide variety of Gram-positive and Gram-negative bacteria, and several mold spores and fungi. Chlorobutanol is widely used in food and cosmetic industry.
BP22476	MCC950 sodium
BP22476	MCC950 Sodium (CP-456773 Sodium, CRID3 sodium salt) is a potent and selective inhibitor of NLRP3 with corresponding IC50 values of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.
BP22478	CY-09
BP22478	CY-09 is a specific inhibitor of the NLRP3 inflammasome and directly targets NLRP3. its IC50 values for the five major cytochrome P450 enzymes were 18.9, 8.18, >50, >50 and 26.0 µM, respectively.
BP22484	IAXO-102
BP22484	IAXO-102 is an antagonist of TLR4 that targets MD-2 and CD14 co-receptors.IAXO-102 inhibits MAPK and p65 NF-κB phosphorylation and downregulates TLR4-dependent pro-inflammatory protein expression.IAXO-102 inhibits the development of experimental abdominal aortic aneurysms.
BP22510	W-54011
BP22510	W-54011 is a potent and orally active non-peptide C5a receptor antagonist. W-54011 inhibits the binding of 125I-labeled C5a to human neutrophils with a Ki value of 2.2 nM. W-54011 also inhibits C5a-induced intracellular Ca2+ mobilization, chemotaxis, and generation of ROS in human neutrophils with IC50s of 3.1 nM, 2.7 nM, and 1.6 nM, respectively.
BP22557	Coenzyme Q10
BP22557	Coenzyme Q10 is an essential cofactor of the electron transport chain and a potent antioxidant agent.
BP22562	Ferrostatin-1
BP22562	Ferrostatin-1 (Fer-1), a potent and selective ferroptosis inhibitor, suppresses Erastin-induced ferroptosis in HT-1080 cells (EC50=60 nM). Ferrostatin-1, a synthetic antioxidant, acts via a reductive mechanism to prevent damage to membrane lipids and thereby inhibits cell death. Antifungal Activity.
BP22570	BRD-K98645985
BP22570	BRD-K98645985 is a BAF (mammalian SWI/SNF) transcriptional repression inhibitor with an EC50 of ~2.37 µM. BRD-K98645985 binds ARID1A-specific BAF complexes, prevents nucleosomal positioning, and potently reverses HIV-1 latency, without T cell activation or toxicity.
BP22483	MD2-TLR4-IN-1
BP22483	MD2-TLR4-IN-1 (compound 22m) is a potent inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4). MD2-TLR4-IN-1 (compound 22m) inhibits lipopolysaccharide ( LPS-induced tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) expression in macrophages with corresponding IC50 values of 0.89 μM and 0.53 μM, respectively.
BP22485	Resatorvid
BP22485	Resatorvid (TAK-242, CLI-095), a small molecule inhibitor of TLR4 signaling pathway, blocks LPS-induced NO, TNF-α, and IL-6 production in macrophages with corresponding IC50 values of 1.8 nM, 1.9 nM, and 1.3 nM. Resatorvid downregulates the expression of TLR4 downstream signaling molecules MyD88 and TRIF. Resatorvid inhibits autophagy.
	(-)-Epigallocatechin Gallate
	(-)-Epigallocatechin Gallate (EGCG) is a potent antioxidant Polyphenol flavonoid isolated from green tea. EGCG inhibits telomerase and DNA methyltransferase, blocks the activation of EGF receptors and HER-2 receptors, inhibits fatty acid synthase and glutamate dehydrogenase activity.
BP22536	Celecoxib
BP22536	Celecoxib,a selective non-steroidal anti-inflammatory drug (NSAID), is a selective COX-2 inhibitor with an IC50 of 40 nM.